Corticosteroids Can Be Used In COVID-19 Treatment, New Studies Show

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One study included in the meta-analysis found that corticosteroids might even increase mortality in non-severe patients. Three studies have shown that these anti-inflammatory drugs can improve the survival of the sickest COVID-19 patients.

Dr. Anthony Gordon of Imperial College London called the result "a huge step forward", but added, "as impressive as these results are, it's not a cure". High-risk people may require admission to the hospital or intensive care unit due to severe symptoms.

As the coronavirus continues to spread throughout the world, researchers are scrambling to develop a vaccine against the virus and treatments for Covid-19, the disease caused by the virus.

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In an accompanying editorial, Hallie Prescott, MD, of the University of MI in Ann Arbor, and Todd Rice, MD, of Vanderbilt University in Nashville, Tennessee, argued that this difference could be explained by the early halt to the trial leaving it "underpowered to adequately evaluate the effect of corticosteroids on mortality". In the second group, steroid treatment improved patient outcomes by 80%. And after struggling to help their community survive the Covid-19 outbreak, Alexander and the rest of the staff now find themselves dealing with another crisis. In the groups that were given the various steroids, 30% roughly died.

It found that corticosteroid treatment led to an estimated 20 per cent reduction in the risk of death. Further, the analysis showed that patients who received steroids consistently demonstrated the survival benefit regardless of which corticosteroid they received, the dose of the steroids, and whether they had been treated with a ventilator or had received supplemental oxygen without being placed on a ventilator.

In the results, the team has revealed that five of the trials reported mortality at 28 days, 1 trial at 21 days, and 1 trial at 30 days. "It's the most solid news we've had yet on how to take care of patients with COVID-19".

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But listing comorbidities alongside COVID-19 does not make those deaths any less attributable to the virus. In addition, states may report deaths at different rates using various reporting systems and methods.


Although evidence is continuing to grow of the effectiveness of steroids in treating hospitalised patients, the World Health Organization has cautioned against their use for individuals with mild symptoms, saying that "indiscriminate use of any therapy for Covid-19 would potentially rapidly deplete global resources and deprive patients who may benefit from it most as potentially life-saving therapy".

Similar guidelines recommending the use of steroids to treat patients with severe Covid-19 have already been issued by the health agencies, including the National Institutes of Health (NIH) and the Infectious Diseases Society of America.

"John Noble Home will continue using our strong infection control measures that are aligned with Ministry of Health and Long Term Care directives and guided by public health authorities", said the notice. Hydrocortisone injected into the vein as a drip instead of a pill form.

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