But Ilija Nestorovski headed in an equaliser before Fofana's brilliant victor in injury time.
Watch Serie A live in the United Kingdom on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Then with the game heading for a 1-1 draw, the hosts stunned Juventus with a 92nd minute victor scored by Seko Fofana. We lost it in the 92nd minute because we wanted to win at all costs.
"In this way we took the game to a risky level, and after the 90th minute, we lost it".
Ronaldo scores twice as Juventus beat Lazio in Serie A
Immobile converted the penalty himself and Szczesny denied Lazio an equaliser when he palmed away a Sergej Milinkovic-Savic free kick.
"In this period, we are physically and mentally exhausted, and it is a problem common to all", the Juventus head coach said.
"At the moment I am not thinking about the Champions League, in my mind, there is only Sampdoria and Sunday's match", he said. A defensive header out came straight to De Ligt and he took one touch before firing powerfully into the bottom left corner.
Back after the break, Nestorovski took advantage of an Alex Sandro error to equalise, getting his head to a cross from on-loan Watford midfielder Ken Sema to beat Szczesny.
"It's hard to keep up mentally and physically for 90 minutes".
Seko Fofana scored the victor for the hosts in second-half injury time to steal all three points from Juventus.
Amber Heard told her mother Johnny Depp was 'violent and crazy'
Mr Holmes texted Ms Heard at around noon to say "on my way to get him", to which Ms Heard replied: "Trying to wake him now". Depp, 57, began taking the other bottles within reach and tossing them in his direction, Heard said.
"We said beforehand that (relegation rivals) Lecce were going strong and we had to push forward".
Cristiano Ronaldo has been overtaken by Lazio striker Ciro Immobile in the golden boot race.
Lazio came from a goal down to defeat Cagliari 2-1 to move to within a point of third-placed Inter Milan.
The victory secured Lazio a spot in next season's Champions League with the capital side now guaranteed at least fourth place in Serie A.
More hot water for NFL’s Redskins as sexual harassment accusations fly
The league said in a statement it will meet with lawyers after the investigation is complete and will act based on the findings. Two female reporters also said they received unwanted advances from Alex Santos , who was the team's director of pro personnel.